Resources and References

Click on the topic below to see a list of resources and references.

  • IV Vitamin C

    [Learn more about High Dose IV Vitamin C]

    [Learn more about IV Vitamin C “Push”]

    Riordan Clinic Articles

    “IV Vitamin C for Cancer” (September 2020) [READ]

    “High-Dose Intravenous Vitamin C as a Successful Treatment of Viral Infections” (May 2020) [READ]

    “Vitamin C Protects Against Coronavirus” (February 2020) [READ]

    “Patient Story: IV Vitamin C During Chemo” (February 2020) [READ]

    “Vitamin C and Cancer” (June 2019) [READ]

    “IV Vitamin C for Cancer” (April 2019) [READ]

    “Intravenous Vitamin C Versus Cancer and Other Killers” (September 2018) [READ]

    “IVC and the Riordan Approach to Adjunctive Cancer Care: 7 Key Questions” (October 2017) [READ]

    “Can Intravenous Vitamin C Stop a Deadly Infection? Mainstream Medicine is Taking Notice” (May 2017) [READ]

    “Intravenous Vitamin C Protects Against Metabolic Syndrome and Activates Nrf2” (February 2017) [READ]

    “High-Dose IV Vitamin C” (September 2016) [READ]

    “Vitamin C and Cancer” (March 2016) [READ]

    “Intravenous Vitamin C in Cancer and Chronic Infections” (March 2016) [READ]

    “Vitamin C and Traditional Chemotherapy” (March 2016) [READ]

    “The Clinical Impact of Vitamin C: My Personal Experiences as a Physician” (September 2014) [READ]

    “Effect of High Dose Vitamin C on Epstein-Barr Viral Infection” (May 2014) [READ]

    “High-Dose Intravenous Vitamin C as a Successful Treatment of Viral Infections” (February 2014) [READ]

    “Vitamin C and Chemotherapy in the News” (February 2014) [READ]

    “Patient Profile: Fighting Fatigue with Intravenous Vitamin C” (February 2014) [READ]


    “Riordan Clinic on Good Day Kansas – IVC Now” (November 2, 2020) [WATCH]

    “The Power of Intravenous Vitamin C with Dr. Ron Hunninghake” (September 18, 2020) [WATCH]

    “IVC Now: The Science of Better Immune Performance” (March 5, 2020) [WATCH]

    “High Dose Vitamin C Kills Cancer Cells” (March 26, 2019) [WATCH]

    “Vitamin C and Infection: New Applications” (March 26, 2019) [WATCH]

    “Vitamin C, Mitochondria, and Cellular Energy” (March 25, 2019) [WATCH]

    “IV Vitamin C: An Adjunctive Cancer Therapy” (October 18, 2018) [WATCH]

    “IV Vitamin C as an Adjunctive Cancer Therapy” (October 24, 2018) [WATCH]

    “High-Dose Vitamin C Therapy for Major Diseases: A Historical Perspective – Andrew Saul, PhD” (January 15, 2018) [WATCH]

    “The Role of Vitamin C in the Management of Viral Diseases – Victor Marcial-Vega, MD” (January 15, 2018) [WATCH]

    “IVC: Nature’s Remedy for Chronic Disease” (October 4, 2017) [WATCH]

    “Lecture: IVC and Mitochondrial Energy” (September 13, 2017) [WATCH]

    “IV Vitamin C (IVC) and Cancer Care” (August 23, 2017) [WATCH]

    “Riordan Clinic: IVC and Cancer-Associated Sepsis” (March 5, 2014) [WATCH]

    “Riordan Clinic Research & IV Vitamin C” (February 13, 2014) [WATCH]

    “IV Vitamin C – Cancer Therapy Plus Much More” (February 24, 2014) [WATCH]

    “Riordan Clinic: IVC Case Studies” (January 23, 2014) [WATCH]

    “Riordan Clinic: IVC, Inflammation, & the Bi-Oxidant Paradox” (January 23, 2014) [WATCH]

    “Riordan Clinic: Live IVC Case Study (By Phone)” (January 23, 2014) [WATCH]

    “Riordan Clinic: Dosing IVC for Cancer Patients (Miranda-Massari and Gonzalez)” (January 23, 2014) [WATCH]

    “Riordan Clinic: Dosing IVC for Cancer Patients (Dr. Levy)” (January 23, 2014) [WATCH]

    “How Vitamin C Fights Cancer” (September 15, 2011) [WATCH]

    “Optimization of Vitamin C and Antioxidant Therapy” (March 4, 2011) [WATCH]

    “Tumors, Their Stroma, and Vitamin C” (January 31, 2011) [WATCH]

    Riordan Clinic Research

    “Private: Vitamin C Research – Tumor Study” [READ]

    “High Dose Intravenous Vitamin C and Chikungunya Fever: A Case Report” [READ]

    “Study of Vitamin C Pharmacology” [READ]

    “Vitamin C and Cancer: Antitumor Activity of Sodium Ascorbate Therapy” [READ]

    “Effects of a High Molecular Mass Convolvulus Arvensis Extract on Tumor Growth and Angiogenesis” [READ]

    “Modulation of Cytokines in Cancer Patients by Intravenous Ascorbate Therapy” [READ]

    “Cancer and Immunology” [READ]

    “The Role of Mitochondria in Cancer and Other Chronic Diseases. Bioenergetics of Human Cancer Cells and Normal Cells During Proliferation and Differentiation”  [READ]

    “Private: Vitamin C Research – IVC” [READ]

    “IVC Protocol”  [READ]

    Peer-Reviewed Articles

    “Efficacy of Continuous Ascorbate Infusion on Lymphopenia and Neutrophil Counts in Cancer Patients” (March 2020) [READ]

    “Continuous Intravenous Vitamin C in the Cancer Treatment: Reevaluation of a Phase I Clinical Study” (March 2019) [READ]

    “Mitochondrial Correction: A New Therapeutic Paradigm for Cancer and Degenerative Diseases” (2018) [READ]

    “Ascorbic Acid and Dehydroascorbic Acid Concentrations in Plasma and Peripheral Blood Mononuclear Cells after Oral Liposomal-Encapsulated or Intravenous Ascorbic Acid Delivery” (August 2017) [READ]

    “Changes in the Rate of PSA Progression and the Level of Alkaline Phosphatase during High Dose Vitamin C Treatment of Patients with Prostate Cancer” (July 2017) [READ]

    “Bioenergetics of Human Cancer Cells and Normal Cells During Proliferation and Differentiation” (March 2017) [READ]

    “Suppression of Alkaline Phosphatase in Prostate Cancer Patients by High Dose Intravenous Vitamin C Treatment: Three Cases” (2017) [READ]

    “High-Dose Intravenous Vitamin C Treatment of a Child with Neurofibromatosis Type 1 and Optic Pathway Glioma: A Case Report” (November 2016) [READ]

    “Intravenous High-Dose Ascorbic Acid Reduces the Expression of Inflammatory Markers in Peripheral Mononuclear Cells of Subjects with Metabolic Syndrome” (June 2016) [READ]

    “Modulation of Cytokines in Cancer Patients by Intravenous Ascorbate Therapy” (January 2016) [READ]

    “The Riordan Intravenous Vitamin C (IVC) Protocol for Adjunctive Cancer Care: IVC as a Chemotherapeutic and Biological Response Modifying Agent” (March 2015) [READ]

    “Effect of High Dose Vitamin C on Epstein-Barr Viral Infection” (May 2014) [READ]

    “High Dose Intravenous Vitamin C and Chikungunya Fever: A Case Report” (2014) [READ]

    “Intravenous Ascorbic Acid Protocol for Cancer Patients: Scientific Rationale, Pharmacology, and Clinical Experience” (August 2013) [READ]

    “Clinical Experience with Intravenous Administration of Ascorbic Acid: Achievable Levels in Blood for Different States of Inflammation and Disease in Cancer Patients” (August 2013) [READ]

    “Effect of High-Dose Intravenous Vitamin C on Inflammation in Cancer Patients” (2012) [READ]

    “Pharmacokinetics of Vitamin C: Insights into the Oral and Intravenous Administration of Ascorbate” (March 2008) [READ]

    “The Effect of High Dose IV Vitamin C on Plasma Antioxidant Capacity and Level of Oxidative Stress in Cancer Patients and Healthy Subjects” (2007) [READ]

    “Schedule-Dependence in Cancer Therapy: What is the True Scenario for Vitamin C?” (2007) [READ]

    “Intravenously Administered Vitamin C as Cancer Therapy Three Cases” (March 2006) [READ]

    “False Positive Finger Stick Blood Glucose Readings After High-Dose Intravenous Vitamin C” (2006) [READ]

    “Vitamin C as an Ergogenic Aid” (2006) [READ]

    “A Pilot Clinical Study of Continuous Intravenous Ascorbate in Terminal Cancer Patients” (December 2005) [READ]

    “Orthomolecular Oncology Review: Ascorbic Acid and Cancer 25 Years Late” (March 2005) [READ]

    “Screening for Vitamin C in the Urine: Is it Clinically Significant?” (2005) [READ]

    “Intravenous Vitamin C as a Chemotherapy Agent: A Report on Clinical Cases” (2004) [READ]

    “Intravenous Ascorbic Acid as a Treatment for Severe Jellyfish Stings” (2004) [READ]

    “Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use” (April 2004) [READ]

    “Intravenous Ascorbic Acid: Protocol for its Application and Use” (September 2003) [READ]

    “Orthomolecular Oncology: A Mechanistic View of Intravenous Ascorbate’s Chemotherapeutic Activity” (March 2002) [READ]

    “Sixteen-Year History with High Dose Intravenous Vitamin C Treatment for Various Types of Cancer and Other Diseases” (2002) [READ]

    “Vitamin C and Oxidative DNA Damage Revisited” (2002) [READ]

    “Cytotoxicity of Ascorbate, Lipoic Acid, and Other Antioxidants in Hollow Fibre in Vitro Tumours” (2001) [READ]

    “The Effect of Alternating Magnetic Field Exposure and Vitamin C on Cancer Cells” (2001) [READ]

    “Clinical and Experimental Experiences with Intravenous Vitamin C” (2000) [READ]

    “Different Fatty Acid Composition Between Normal and Malignant Cell Lines” (1999) [READ]

    “High-Dose Intravenous Vitamin C in the Treatment of a Patient with Renal Cell Carcinoma of the Kidney” (1998) [READ]

    “Intravenous Vitamin C in a Terminal Cancer Patient” (1996) [READ]

    “High Dose Intravenous Vitamin C and Long Time Survival of a Patient with Cancer of Head of the Pancreas” (1995) [READ]

    “Intravenous Ascorbate as a Tumor Cytotoxic Chemotherapeutic Agent” (1995) [READ]

    “Case Study: High-Dose Intravenous Vitamin C in the Treatment of a Patient with Adenocarcinoma of the Kidney” (1990) [READ]

  • Mistletoe Therapy

    [Learn more about Mistletoe Therapy]

    Riordan Clinic Articles

    “Mistletoe Therapy for Cancer Treatment” (January 2021) [READ]

    “Choosing Naturopathic Oncology” (January 2021) [READ]

    “Mistletoe Therapy for Cancer Treatment” (January 2021) [READ]

    “Bridging the Gap in Cancer Care” (September 2020) [READ]

    “Cancer-Related Fatigue” (August 2019) [READ]

    “Fighting Cancer with Ancient Medicine: Mistletoe Therapy” (October 2018) [READ]


    “Dr. Lucas Times – Cancer and How to Treat It” (September 6, 2020) [WATCH]

    “Mistletoe (Part 1): A Beneficial Supplement in Integrative Cancer Care” (November 15, 2018) [WATCH]

    “Mistletoe (Part 2: A Beneficial Supplement in Integrative Cancer Care” (November 15, 2018) [WATCH]

  • Chelation Therapy

    [Learn more about Chelation Therapy]

    Riordan Clinic Articles

    “Coping with the Aftermath of Vital Infection Understanding ‘Long-Haul’ COVID” (February 2021) [READ]

    “The 10 Most Toxic Minerals” (July 2016) [READ]

    “Keep Your Pump and Pipes Working” (January 2016) [READ]

    “Chelation Therapy” (January 2016) [READ]

    “Chelation and Metal Intoxication” (December 2013) [READ]

    “DETOX: Natural Cleansing to Remove Body Toxins” (November 2011) [READ]

    “What are Aluminum, Lead, Cadmium, and Mercury in Our Bodies” (November 2008) [READ]

    “TACT – Trial to Assess Chelation Therapy” (January 2001) [READ]

    “Why EDTA Chelation Therapy” (June 1998) [READ]

    “A Look at Chelation” (May 1996) [READ]


    “Riordan Clinic – How Does the Detox Program Work?” (November 27, 2013) [WATCH]

    “How Chelation Works to Improve Circulation” (September 15, 2011) [WATCH]

    “Chelation – What Does it Do?” (October 29, 2010) [WATCH]

    “Chelation – Key Questions” (October 29, 2010) [WATCH]

    “Chelation – To Combat Heart Disease” (October 29, 2010) [WATCH]

    Riordan Clinic Research

    “Chelation Therapy Study” [READ]

    Peer-Reviewed Articles

    “What is Chelation Therapy” [READ]

    “Chelation Therapy: A Controversial Heart Treatment?”[READ]

    “Chelation Therapy: An Autism Cure?” [READ]

    “Choosing Chelation?” [READ]

    “Treating Myelodysplastic Syndromes” (April 2020) [READ]

    “Metabolic Correction for Attention-Deficit/ Hyperactivity Disorder: A Biochemical-Physiological Therapeutic Approach” (January 2013) [READ]

    “EDTA Chelation Therapy in the Treatment of Toxic Metals Exposure” (2011) [READ]

    “Efficacy of Oral DMSA and Intravenous EDTA in Chelation of Toxic Metals and Improvement of the Number of Stem/ Progenitor Cells in Circulation” (2011) [READ]

    “Intravenous EDTA Chelation Treatment of a Patient with Atherosclerosis” (1999) [READ]

    “Coronary Artery Occlusion, Chelation and Cholesterol in a 49-Year Old Pilot” (1996) [READ]

    “Improvement of Essential Hypertension after EDTA Intravenous Infusion” (1992) [READ]

    “Mineral Excretion Associated with EDTA Chelation Therapy” (Summer 1990) [READ]

    “EDTA Chelation/ Hypertension Study: Clinical Patterns as Judged by the Cornell Medical Index Questionnaire” (1989) [READ]

    “Electrocardiographic Changes Associated with EDTA Chelation Therapy” (Winter 1988) [READ]

    “The Effects of Intravenous EDTA Infusion on the Multichemical Profile” (October 1988) [READ]

    “Another Look at Renal Function and the EDTA Treatment Process” (1987) [READ]

  • Bioidentical Hormone Replacement Therapy

    [Learn more about Bioidentical Hormone Replacement Therapy]

    Riordan Clinic Articles

    “Is Bioidentical Hormone Replacement Therapy Right for You?” (October 2020) [READ]

    “Bioidentical Hormone Replacement Therapy” (July 2020) [READ]

    “A Lifetime of Progesterone” (January 2018) [READ]

    “The Value of Anti-Aging Hormone Monitoring” (September 2017) [READ]

    “In Defense of Estrogen” (December 2016) [READ]

    “Your Hormones: Why You Need Them, Why You Can’t Live Without Them” (July 2014) [READ]

    “Holistic Approaches to Hormone Therapy” (July 2014) [READ]

    “Are Bio-Identical Hormones Safe?” (July 2013) [READ]

    “Natural Options for Hormone Replacement Therapy” (April 1997) [READ]


    “Women’s Health Series: Balanced Hormones Throughout Your Lifetime” (January 17, 2018) [WATCH]

    “Why Does Riordan Clinic use Bio-Identical Hormone Replacement Therapy?” (January 18, 2017) [WATCH]

    “Exploring Bioidentical Hormone Replacement Therapy” (August 25, 2014) [WATCH]

    “Bioidentical Hormones: Are They Safe?” (August 19, 2013) [WATCH]

    “Balancing Hormones for the Natural Treatment of PMS and Other Female Disorders” (November 7, 2011) [WATCH]

  • Regenerative Injection Therapy

    [Learn more about Regenerative Injection Therapy]

    [Learn more about Prolozone Therapy]

    Riordan Clinic Articles

    “Can Regenerative Medicine Take the Place of Surgery?” (October 2020) [READ]

    “Regenerative Injection Therapy” (June 2020) [READ]

    “Prolozone Therapy” (June 2020) [READ]

    “Regenerative Injection Therapies” (June 2018) [READ]

    “Prolozone: For Resolving Chronic Pain Patterns and Regenerating Damaged Tissues” (March 2017) [READ]


    “Discovering Real Health: Regenerative Medicine” (June 16, 2020) [WATCH]

    “Regenerative Injection Therapies for Arthritis and Pain” (June 20, 2018) [WATCH]

    “What is Prolozone Therapy?” (January 18, 2017) [WATCH]

    Research and References

    1. Dagenais S, Yelland MJ, Del Mar C, et al. Prolotherapy injections for chronic low-back pain. Cochrane Database Syst Rev. Apr 18 2007(2):CD004059. PMID 17443537.

    2. Dagenais S, Mayer J, Haldeman S, et al. Evidence-informed management of chronic low back pain with prolotherapy. Spine J. Jan-Feb 2008;8(1):203-212. PMID 18164468.

    3. Chou R, Atlas SJ, Stanos SP, et al. Nonsurgical interventional therapies for low back pain: a review of the evidence for an American Pain Society clinical practice guideline. Spine (Phila Pa 1976). May 1 2009;34(10): 1078-1093. PMID 19363456.

    4. Dagenais S, Haldeman S, Wooley JR. Intraligamentous injection of sclerosing solutions (prolotherapy) for spinal pain: a critical review of the literature. Spine J. May-Jun 2005;5(3):310-328. PMID 15863087.

    5. Rabago D, Best TM, Beamsley M, et al. A systematic review of prolotherapy for chronic musculoskeletal pain. Clin J Sport Med. Sep 2005;15(5):376-380. PMID 16162983.

    6. Yelland MJ, Mar C, Pirozzo S, et al. Prolotherapy injections for chronic low-back pain. Cochrane Database Syst Rev. Apr 2004(2):CD004059. PMID 15106234.

    7. Yelland MJ, Glasziou PP, Bogduk N, et al. Prolotherapy injections, saline injections, and exercises for chronic low-back pain: a randomized trial. Spine (Phila Pa 1976). Jan 1 2004;29(1):9-16; discussion 16. PMID 14699269.

    8. Klein RG, Eek BC, DeLong WB, et al. A randomized double-blind trial of dextrose-glycerine-phenol injections for chronic, low back pain. J Spinal Disord. Feb 1993;6(1):23-33. PMID 8439713.

    9. Ongley MJ, Klein RG, Dorman TA, et al. A new approach to the treatment of chronic low back pain. Lancet. Jul 18 1987;2(8551):143-146. PMID 2439856.

    10. Dagenais S, Ogunseitan O, Haldeman S, et al. Side effects and adverse events related to intraligamentous injection of sclerosing solutions (prolotherapy) for back and neck pain: A survey of practitioners. Arch Phys Med Rehabil. Jul 2006;87(7):909-913. PMID 16813776.

    11. Kim WM, Lee HG, Jeong CW, et al. A randomized controlled trial of intra-articular prolotherapy versus steroid injection for sacroiliac joint pain. J Altern Complement Med. Dec 2010;16(12):1285-1290. PMID 21138388.

    12. Reeves KD, Hassanein KM. Long-term effects of dextrose prolotherapy for anterior cruciate ligament laxity. Altern Ther Health Med. May-Jun 2003;9(3):58-62. PMID 12776476.

    13. Jahangiri A, Moghaddam FR, Najafi S. Hypertonic dextrose versus corticosteroid local injection for the treatment of osteoarthritis in the first carpometacarpal joint: a double-blind randomized clinical trial. J Orthop Sci. Sep 2014;19(5):737-743. PMID 25158896.

    14. Rabago D, Patterson JJ, Mundt M, et al. Dextrose prolotherapy for knee osteoarthritis: a randomized controlled trial. Ann Fam Med. May-Jun 2013;11(3):229-237. PMID 23690322.

    15. Rabago D, Mundt M, Zgierska A, et al. Hypertonic dextrose injection (prolotherapy) for knee osteoarthritis: Long term outcomes. Complement Ther Med. Jun 2015;23(3):388-395. PMID 26051574.

    16. Reeves KD, Hassanein K. Randomized prospective double-blind placebo-controlled study of dextrose prolotherapy for knee osteoarthritis with or without ACL laxity. Altern Ther Health Med. Mar 2000;6(2):68-74, 77-80. PMID 10710805.

    17. Reeves KD, Hassanein K. Randomized, prospective, placebo-controlled double-blind study of dextrose prolotherapy for osteoarthritic thumb and finger (DIP, PIP, and trapeziometacarpal) joints: evidence of clinical efficacy. J Altern Complement Med. Aug 2000;6(4):311-320. PMID 10976977.

    18. Rabago D, Best TM, Zgierska AE, et al. A systematic review of four injection therapies for lateral epicondylosis: prolotherapy, polidocanol, whole blood and platelet-rich plasma. Br J Sports Med. Jul 2009;43(7):471-481. PMID 19028733.

    19. Scarpone M, Rabago DP, Zgierska A, et al. The efficacy of prolotherapy for lateral epicondylosis: a pilot study. Clin J Sport Med. May 2008;18(3):248-254. PMID 18469566.

    20. Carayannopoulos A, Borg-Stein J, Sokolof J, et al. Prolotherapy versus corticosteroid injections for the treatment of lateral epicondylosis: a randomized controlled trial. PM R. Aug 2011;3(8):706-715. PMID 21871414.

    21. Yelland MJ, Sweeting KR, Lyftogt JA, et al. Prolotherapy injections and eccentric loading exercises for painful Achilles tendinosis: a randomised trial. Br J Sports Med. Apr 2011;45(5):421-428. PMID 19549615.

    22. American Association of Orthopedic Medicine, Klein RG, Patterson J, et al. Prolotherapy for Back Pain Treatment. n.d.; Accessed October 7, 2019.

    23. Centers for Medicare and Medicaid Services. National Coverage Determination (NCD) for PROLOTHERAPY, Joint Sclerotherapy, and Ligamentous Injections with Sclerosing Agents (150.7). 1999; AAQAAAAAAA&. Accessed October 7, 2019.