A Unified Theory of Chronic Illness – Ron Hunninghake, MD
Dr. Ron Hunninghake, The chief medical officer of the Riordan Clinic, will deliver an overture introduction to the theme of the 2016 Symposium: The Emergence of Redox Medicine and the Development of a Unified Theory of Chronic Illness.
Curing Lyme and Other Chronic Infections – Thomas Levy, MD, JD
Lyme disease is a debilitating disease for many who contract it, and when traditional antibiotic therapy is only marginally effective or completely ineffective, little is currently offered these patients that can make a significant impact on improving the daily quality of their lives. The CDC currently estimates that there are 300,000 newly infected patients in the United States every year.
There remains a great deal of controversy whether some chronically ill Lyme patients have other ineffectively-treated pathogens keeping them ill, or whether these patients have somehow developed chronic degenerative diseases that have nothing to do with Lyme and Lyme-related pathogens but remained misdiagnosed as victims of Lyme disease. Nevertheless, it will be shown that Ascorbazone therapy is proving to be highly effective in both resolving clearly diagnosed Lyme cases while offering a great deal of improvement to the improperly diagnosed patient as well.
Ascorbazone therapy focuses on a goal of vitamin C (ascorbate) saturation throughout the body, with the addition of the potent anti-pathogen impact of properly-applied ozone-based therapies.
The presentation will discuss why Ascorbazone therapy is highly effective in curing, or at least clinically resolving, chronic Lyme patients, since Lyme antibodies can persist long after the infection has been resolved, allowing the academic argument of whether the infection is really gone to persist. Supporting scientific literature for the efficacy of ascorbate and ozone will be cited, and case reports will be presented and discussed as well.
IVC Rates of Infusion as an Inflammation Modulating Technique – Paul S. Anderson, NMD
Ascorbic acid, when infused, has variable pharmacokinetics as well as cellular and chemokine effects. These basics are well documented but in many cases poorly understood clinically. In this presentation Dr. Anderson will use the latest data as well as clinical experience to develop a clearer understanding regarding the use of the variable kinetics in service of cytokine modulation and clinical outcome. Additionally he will use recent data to underscore the role ascorbate can play in epigenetic modification.
At the end of this presentation the attendee will have an understanding of the ability to modulate effects of intravenous ascorbic acid based on infusion rate and dose.
The ABCs of the Riordan IVC Protocol – Thomas E. Levy, MD, JD
The scientific basis of highly-dosed antioxidant therapy, especially vitamin C, will be presented and discussed. In particular, the unified theory of increased oxidative stress underlying all chronic disease will be outlined, with particular emphasis on the role of toxins always causing this increased oxidative stress. With this backdrop of information, the reasons why vitamin C is the antitoxin of choice for all poisonings/intoxications will be addressed. Along the same lines, the reasons why vitamin C should always be an essential part of the treatment for any infectious disease or disorder will also be discussed.
The above information will then lead into a discussion of the most important factors or promoters of all chronic degenerative diseases, along with why the regular dosing of vitamin C and other vital antioxidants should always be part of the protocols for addressing these factors.
A large portion of the presentation will finally address the many ways in which vitamin C can be administered in a treatment protocol, with emphasis on highly-dosed intravenous applications, and the multiple factors that need to be considered in order to achieve optimal clinical outcomes with intravenous application. The benefits of the Multi-C Protocol will be analyzed, and the importance of utilizing Mop-Up IVs as low-dose, slowly-infused vitamin C infusions will be presented as well.
The Evolution of the Riordan IVC Protocol – Ron Hunninghake, MD
UBI (Ultraviolet Blood Irradiation) Treatment for Chronic Infections – speaker TBD
Ultraviolet Blood Irradiation (UBI) is a procedure that exposes the blood to light to heighten the body’s immune response and to kill infections. With exposure to UV light, bacteria and viruses in your bloodstream absorb five times as much photonic energy as do your red and white blood cells.
This means the fragments of the killed infecting agents create a safe, autogenous vaccination-like response. This further activates and directs your immune system to the specific infections your body is attempting to overcome. The net result is the induction of a secondary kill of these infecting agents throughout the entire body. Treating only 35 cc of blood with UBI induces a beneficial systemic response.
The amount of treatment needed is determined by variables such as the state of health of the patient’s immune system, length of time the patient has been ill, and the severity of the disease being treated. UBI can be used clinically as both a SPECIFIC (i.e. psoriasis, lymph cancer) and NON-SPECIFIC (chronic infections, chronic fatigue, auto-immune diseases, etc.) immune modulating therapy, as noted in published studies.
Food as Medicine – Jennifer Mead, ND and Anne Zauderer, DC
In a very compact 90 minute presentation on healthy eating and optimal food selection, this dynamic duo will demonstrate that indeed, as Hippocrates stated, food is the essential medicine for chronic illness.
High-Dose Vitamin C Therapy for Major Diseases: A Historical Perspective – Andrew Saul, PhD
Therapeutic uses of vitamin C were advocated by physicians almost immediately after ascorbic acid was isolated. Notable early pioneers of high-dose vitamin C therapy include Claus Washington Jungeblut, MD (1898-1976); William J. McCormick, MD (1880-1968); and Frederick R. Klenner, MD (1907-1984). More recently, important work has been published by Hugh D. Riordan, MD (1932-2005) and Robert F. Cathcart III, MD (1932 – 2007). Jungeblut first published on ascorbate as prevention and treatment for polio, in 1935. Also in 1935, Jungeblut showed that vitamin C inactivated diphtheria toxin. By 1937, Jungeblut demonstrated that ascorbate inactivated tetanus toxin. Between 1943 and 1947, Klenner, a specialist in diseases of the chest, cured 41 cases of viral pneumonia with vitamin C. By 1946, McCormick showed how vitamin C prevents and also cures kidney stones; by 1957, how it fights cardiovascular disease. Beginning in the 1960s, Robert F. Cathcart, M.D. used large doses of vitamin C to treat influenza, pneumonia, hepatitis, and, eventually, AIDS. For more than fourdecades, beginning in 1975, Hugh D. Riordan, M.D. and his team have successfully used large doses of intravenous vitamin C against cancer. The medical literature has largely ignored 80 years of physician reports and laboratory and clinical studies on successful high-dose ascorbate therapy.
Oral and Topical Use of Vitamin C in Clinical Practice: Case Reports and Pearls for the Parent or Practitioner. – Suzanne Humphries, MD
Intravenous ascorbate is not the only means for bringing the power of this life saving molecule to the rescue of the ever growing number of chronically ill patients descending upon modern medicine. Dr. Humphries will discuss successful case histories in the use of the many forms, dosages, and delivery methods of oral and topical ascorbate
Painless Oral Infections Cause Chronic Diseases – Thomas E. Levy, MD, JD
The current medical literature now clearly demonstrates that root canal-treated teeth are all sites of chronic focal infection, as well as producers of highly potent toxins produced by dental pathogens under anaerobic conditions. In addition to demonstrating why the root canal procedure will always result in chronic infection, multiple studies will be cited to show that the chronic inflammation and pathogen presence now known to initiate coronary atherosclerosis virtually always originates from oral infections, typically from periodontitis or chronically infected teeth, especially root canals.
It will also be shown that there are a large number of undiagnosed, asymptomatic teeth with X-ray evidence of chronic apical periodontitis (CAP), a radiological finding that is only present when the pulp of the tooth is infected and necrotic. It will be shown that these teeth are even more prone to cause heart attacks than has been proven to be the case with root canal-treated teeth, which are also teeth that very frequently demonstrate CAP. A number of current articles in the dental literature will be cited to demonstrate not only this cause-and- effect cardiac connection, but also to demonstrate the many links of these infected teeth to a wide variety of chronic degenerative diseases.
The very important practical point will be made that the patient with suspected or established cardiac disease must always have 3D Digital X-ray examination of their teeth to look for chronic apical periodontitis, since regular dental X-rays miss very many teeth with clear infectious pathology. The case will be made that strong consideration must be given to having these teeth properly extracted with the sockets cleaned and debrided to prevent or limit the possibility of future cardiac events.
Golden Cells and Mesenchymal Molecules – Neil Riordan, PhD
Son of Dr. Hugh Riordan, the founder of Medistem, will explain how mesenchymal stem cells and the molecular products that they produce are the key to not only maintaining health but successfully recovering from severe “untreatable” chronic illnesses.
The Role of Vitamin C in the Management of Viral Diseases – Victor Marcial-Vega, MD
As one of the rare oncologists to fully embrace the utility of IVC in the care of chronic illness, Dr. Victor brings to the conference an astounding knowledge of the basic mechanisms of ascorbate in the care and often cure of otherwise debilitating and sometimes lethal viral illnesses.
High-Dose Intravenous Vitamin C as Therapy for Patients with Cancer. – Nina Mikirova, PhD
Vitamin C has been shown to protect against oxidant injury at physiological concentrations and has been suggested as having both a preventative and therapeutic role in a number of pathologies when administered at pharmacological levels.
In our clinic we treat cancer patients by high doses of vitamin C intravenously during 40 years. At the same time, Riordan Clinic Research Institute (RCRI) has been researching the potential of intravenous vitamin C therapy for over 30 years. Our efforts have included in vitro studies, animal studies, pharmacokinetic analyses, and clinical trials.
The results of our studies and rationales for using intravenous ascorbate infusions to treat cancer are discussed in presentation.
According to our studies high dose vitamin C has anticancer properties, including ability to induce tumor cell apoptosis, inhibit angiogenesis, and reduce inflammation. The positive response to IVC was demonstrated by measurements of tumor markers, inflammation (C- reactive protein) and inflammatory/angiogenesis cytokines (total 174 cytokines).
In recent years there were studies showing that ascorbic acid has effect on gene expression and epigenetic phenomena. We demonstrated by using animal model, the effect of pharmacological concentrations of ascorbic acid on several gene expressions involved in tumorigenesis.
Our Phase I clinical study and other trials indicated that IVC can be administered safely with relatively few adverse effects.
Clinical studies of chemotherapy with vitamin C demonstrated that IVC does not interfere with anti-tumor effects of chemotherapy. IVC may improve time to relapse, enhance reductions in tumor mass and improve survival in combination with chemotherapy. IVC treatment improves quality of life, physical function, and toxicities associated with chemotherapy.
Safe IVC: Patient Selection, Mixing, Infusion – Ron Hunninghake, MD
Megadose of Ascorbic Acid in Chronic and Degenerative Diseases – Milton Fernando Pinto, MD
We’ll begin with the history of vitamin C that can be tracked back to the fifteenth century ship voyages from Europe to America. Then we’ll stop in Dr. Irwin Stone, who gives us the scientific guideline for the administration of megadoses of ascorbic acid. We´ll follow the scientific support of the use of humankind of megadoses of ascorbic acid, administered in different diseases, surgeries and organ transplants. It is important to address about scurvy and various pathological manifestations caused by the lack of collagen. And finally we’ll remark the effectiveness with megadoses of ascorbic acid, depending on the quality and quantity of vitamin C, in our practice in diseases such as cancer, diabetes and HPV.
Death by Calcium – Thomas Levy, MD, JD
There is no question that calcium is an essential nutrient, without which normal cellular function and survival are impossible. However, it is now being recognized that as essential as calcium is for cellular health, its excess presence inside the cell is also highly toxic. In fact, along with iron, another toxic nutrient, excess intracellular calcium appears to be one of the natural mechanisms by which malignant transformation is initiated and promoted.
The vast majority of adults, especially older ones, have a chronic excess of calcium inside their cells. The chronic release of calcium from aging bone, most pronounced in osteopenia and osteoporosis, fuels much of this excess calcium dissemination. Any form of calcium supplementation further adds to this excess. Widespread metastatic calcifications typically result, many of which are only detectable by sophisticated imaging techniques. The scientific evidence indicates that all cancer cells have significantly elevated levels of intracellular calcium, with pronounced increases in oxidative stress. Lesser elevations of intracellular calcium also reliably result in cellular dysfunction, and this is a common denominator in all chronic degenerative diseases.
For those who supplement calcium, the problem is further exacerbated. Very recent research shows that those who take the most calcium, whether from supplements, dairy, or both, die the soonest. Of particular interest is that all-cause mortality is increased, not just heart disease, as has long been assumed to be the case by many researchers. Measures that limit the generalized uptake of calcium by the cells decrease all-cause mortality.
Specific measures on how to best regulate calcium in the body are discussed. Supplementation regimens will be discussed, along with the scientific literature that clearly backs their beneficial impact on stopping and even reversing the physiology of osteoporosis, while decreasing all-cause mortality and lessening the impact of all the other chronic degenerative diseases.
Therapeutic Magnesium is a ReDox Miracle – Carolyn Dean, MD, ND
We know that Redox Medicine and Redox Therapy can heal most of our chronic diseases but they will continue to be ignored by allopathic medicine because they are not drug-based. It is up to the IVC community to spearhead this work to which Dr Dean offers groundbreaking information on the use of therapeutic magnesium as the most important Redox nutrient we have available.
The most important redox function of magnesium is its action as a modulator of oxidative phosphorylation during which electrons are transferred from electron donors to electron acceptors creating an electron transport chain that forms a series of protein complexes within the cell’s mitochondria that release energy or ATP. Without this Redox function of magnesium, we would have no life force – no energy.
Until now, we have only been able to achieve high levels of magnesium through IV administration. That has all dramatically changed with the use of ReMag, a fully absorbed, stabilized ionic form of non-laxative magnesium.
Dr Dean will discuss the top 15 functions of magnesium, plus the 56 conditions that occur due to magnesium deficiency and the 100 factors that deplete a person of magnesium. Magnesium is truly a miracle, yet, most allopathic doctors call magnesium a simple laxative!
Mood BioChemistry in Women – Phylis Bronson, Ph.D.
Dr. Bronson’s original research defined the molecular difference between real progesterone and synthetic progestins promoted by the pharmaceutical companies, and the connection to mental health. Based on this scientific information, it is now clear why women have responded badly to synthetic hormones.
The GI Tract-The Epicenter for Chronic Disease – Tom Taxman, MD
Working as a pediatric gastroenterologist in Cleveland, Dr. Taxman has observed how got dysfunction typically plays a central role in most if not all chronic illness. He will share an exciting new way to break the enteropathic cycle “the leaky gut.”
Oxidative Medicine – Nia Stephanopoulos-Chichura, MD
Dr. Nia is a graduate of the University of Kansas integrative medicine fellowship program. Recently having joined the staff of Riordan Clinic she is excited to share her understanding of the fundamental basis of life and health: oxygen metabolism! She will share insights into how IVC, ozone therapies, and oxidative signaling all can be orchestrated to both prevent and treat chronic illness
Nutrigenomics, Methylation, and Organic Acids: Where the Pathways Cross – Matthew Pratt-Hyatt, PhD
Improved technology has brought the realization of personalized medicine closer to a reality. The goal of personalized medicine is to have custom designed treatment plans for each l patient. Two of the most important tools to make this new frontier of medicine functional are the Organic Acids Test (which is a metabolic assessment of overall health) and genetic screening. These two tests work in tandem to help practitioners understand what is happening in the patient’s body by assessing the results of the
Organic Acids Test (OAT), and then using a genetic test to determine the best course of treatment. These two tests are imperative in assessing neurotransmitter metabolism, the methylation pathway, detoxification, and oxalate metabolism. For the methylation pathway we recommend looking at ten different genes. These include MTHFR, MTR, MTRR, CBS, BHMT, AHCY, NOS3, SHMT1, SUOX, and VDR. There are complementary nutritional markers assessed in the Organic Acids Test that help these enzymes work more efficiently, including vitamins B6 and B12.
The second pathway, which is supported by the methylation pathway, is neurotransmitter biosynthesis and metabolism. Three of the best markers in the OAT for measuring neurotransmitter metabolism are homovanillic acid (a dopamine metabolite), vanilymandelic acid (epinephrine/norepinephrine), and 5-HIAA (serotonin, marker). These markers are the metabolites of the neurotransmitters by the enzymes MAOA and COMT, two genes which possess common polymorphism. Deficiencies in these enzymes due to faulty SNPs may cause low neurotransmitter levels, which may also be caused by low amounts of precursors, cofactors, or increased inhibitors.
Two other pathways that are easily monitored by an Organic Acids Test and genetic test are the detoxification pathway and the oxalate metabolism pathway. Detoxification is so important in today’s industrial, polluted, and toxic world. Oxalates are crystalline molecules that we absorb from our diet (high oxalate foods) or are produced by an infection, like yeast/fungal overgrowth. These oxalates can accumulate in the body and cause inflammation. Assessing these two pathways through an Organic Acids Test and genetic screening can be very beneficial for improved health.
IVC & The Law – Thomas E. Levy, MD, JD
The legal premise already exists that no doctor has the right to deny any patient a therapy that is established to be safe, effective, and inexpensive. Based on this premise as well as the corollary premise that no hospital, doctor, or group of doctors has the right to prevent another doctor from administering such a therapy, this presentation will provide the evidence establishing the safe, effective, and inexpensive nature of vitamin C, along with the legal authority mandating its usage.
The presentation will outline the pertinent history of vitamin C therapy, along with the scientific literature documentation establishing its benefit in the past. More current data, with more modern research methods, will further demonstrate the unique benefits of vitamin C in infections, toxin neutralization, and the alleviation of chronic disease symptomatology. The scientific documentation establishing the enormous safety of vitamin C will then be presented.
Once the efficacy, safety, and economy of vitamin C