Efficacy of Continuous Ascorbate Infusion on Lymphopenia and Neutrophil Counts in Cancer Patients

Nina Mikirova, PhD Journal of Translational Science
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Mitochondrial Correction: A New Therapeutic Paradigm for Cancer and Degenerative Diseases

Michael J Gonzalez; Thomas Seyfried; Garth L. Nicolson; Barry J Barclay; Jaime Matta; Alex Vasquez; Dominic D’ Agostino; Jose Olalde; Jorge Duconge; Ron Hunninghake; Miguel J Berdiel; Amanda Cintrón Journal of Orthomolecular Medicine | August 2018 | Volume 33 Number 4
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Continuous Intravenous Vitamin C in the Cancer Treatment: Reevaluation of a Phase I Clinical Study

Nina Mikirova, PhD, Joseph Casciari, PhD, Ronald Hunninghake, MD Functional Foods in Health and Disease
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Changes in the rate of PSA progression and the level of alkaline phosphatase during high dose vitamin C treatment of patients with prostate cancer

Nina Mikirova, Ronald Hunninghake Functional Foods in Health & Disease Vol 7, No 7 (2017)
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Suppression of Alkaline Phosphatase in Prostate Cancer Patients by High Dose Intravenous Vitamin C Treatment: Three Cases

Author(s): Nina A Mikirova, PhD1; Ronald E Hunninghake, MD2 Journal of Orthomolecular Medicine Volume 32, Number 2, 2017
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Bioenergetics of Human Cancer Cells and Normal Cells During Proliferation and Differentiation

Nina A. Mikirova¹, Joseph J. Casciari¹, *Michael J. Gonzalez², Jorge R. Miranda-Massari³, Neil H. Riordan¹ and Jorge Duconge³ Cancer Therapy & Oncology International Journal
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High-Dose Intravenous Vitamin C Treatment of a Child with Neurofibromatosis Type 1 and Optic Pathway Glioma: A Case Report

Nina Mikirova, Ronald Hunninghake, Ruth C. Scimeca, Charles Chinshaw, Faryal Ali, Chris Brannon, Neil Riordan American Journal of Case Reports 2016.10.24
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Bioenergetics of Human Cancer Cells and Normal Cells

Dr. Nina A. Mikirova British Journal of Medicine & Medical Research 7(12): XX-XX, 2015, Article no. BJMMR.2015.412
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The Role of Mitochondria in Cancer and Other Chronic Diseases

Dorothy D Zeviar, Michael J Gonzalez, Jorge R Miranda Massari, Jorge Duconge, Nina Mikirova Journal of Orthomolecular Medicine, 2014, Vol 29, No 4: 157-166
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Intravenous ascorbic acid protocol for cancer patients: scientific rationale, pharmacology, and clinical experience

Mikirova NA, Casciari JJ Hunninghake RE, Riordan NH Functional Foods in Health and Disease, 2013, 3(8):344-366 (Aug 2013)
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Clinical experience with intravenous administration of ascorbic acid: achievable levels in blood for different states of inflammation and disease in cancer patients

Mikirova NA, Casciari JJ, Riordan NH and Hunninghake RE Journal of Translational Medicine, 2013, 11:191 (Aug 2013), doi:10.1186/1479-5876-11-191
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Effect of high-dose intravenous vitamin C on inflammation in cancer patients

Mikirova NA, Casciari JJ, Taylor PR and Rogers AM Journal of Translational Medicine, 2012, 10:189 (Sep 2012), doi:10.1186/1479-5876-10-189
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Increased Level of Circulating Endothelial Microparticles and Cardiovascular Risk Factors

Mikirova NA, Casciari JJ, Hunninghake RE and Riordan NH Journal of Clinical & Experimental Cardiology 2011, 2:4 (1 April 2011)
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Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?

Ichim TE, Minev B, Braciak T, Luna B, Hunninghake R, Mikirova NA, Jackson JA, Gonzalez MJ, Miranda Massari JR, Alexandrescu DT, Dasanu C, Bogin V, Ancans J, Stevens RBRIAN, Markosian B, Koropatnick J, Chen CS, Riordan NH Journal of Translational Medicine 2011, 9:25 (4 March 2011)
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Mitochondria, Energy and Cancer: The Relationship with Ascorbic Acid

Gonzalez MJ, Rosario-Perez G, Guzman AM, Miranda-Massari JR, Duconge J, Lavergne J, Fernandez N, Ortiz N, Quintero del Rio AI, Mikirova NA, Riordan NH, Ricart CM Orthomolecular Medicine, 2010, 25(1):29-38
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Vitamin D Concentrations, Endothelial Progenitor Cells, and Cardiovascular Risk Factors

Mikirova NA, Belcaro G, Jackson JA, Riordan NH Panminerva Medica 2010, 52:(Suppl. 1 to No. 2) (June 2010)
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Nutraceutical Augmentation of Circulating Endothelial Progenitor Cells and Hematopoietic Stem Cells in Human Subjects

Mikirova NA, Jackson JA, Hunninghake R, Kenyon J, Chan KWH, Swindlehurst CA, Minev B, Patel A, Murphy MP, Smith L, Ramos F, Alexandrescu D, Ichim TE, Riordan NH Journal of Translational Medicine 2010, 8:34 (5 Feb 2010)
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Ascorbate inhibition of angiogenesis in aortic rings ex vivo and subcutaneous Matrigel plugs in vivo

Mikirova NA, Casciari JJ, Riordan NH Journal of Angiogenesis Research 2010, 2:2 (18 Jan 2010)
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Circulating endothelial progenitor cells: a new approach to anti-aging medicine?

Mikirova NA, Jackson JA, Hunninghake R, Kenyon J, Chan KWH, Swindlehurst CA, Minev B, Patel AN, Murphy MP, Smith L, Alexandrescu DT, Ichim TE, Riordan NH Journal of Translational Medicine 2009, 7:106 (15 Dec 2009)
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Inhibition of Intracranial Glioma Growth by Endometrial Regenerative Cells

Han X, Meng X, Yin Z, Rogers A, Zhong J, Rillema P, Jackson J, Ichim T, Minev B, Carrier E, Patel A, Murphy M, Min W, Riordan N Cell Cycle, 2009, 8(4):1-5 Feb
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A Child with Metastatic Sarcoma and a Patient with Cancer of the Head of the Pancreas

Jackson J, Hunninghake R, Kirby R, Krier C, Lewis R Orthomolecular Medicine, 2008, 23(1):41-42
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Anti-angiogenic Effect of High Doses of Ascorbic Acid

Mikirova N, Ichim T, Riordan N Journal of Translational Medicine, 2008, 6:50
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Granulocyte Activity in Patients with Cancer and Healthy Subjects

Mikirova N, Klykov A, Jackson J, Riordan N Cancer Biology and Therapy, 2008, 7(9):41-46
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Differential Effect of Alpha-lipoic Acid on Healthy Peripheral Blood Lymphocytes and Leukemic Cells

Mikirova N, Jackson J, Riordan N Orthomolecular Medicine, 2008, 23(2):83-89
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The Effect of High Dose IV Vitamin C on Plasma Antioxidant Capacity and Level of Oxidative Stress in Cancer Patients and Healthy Subjects

Mikirova N, Jackson J, Riordan N Orthomolecular Medicine, 2007, 22(3):153-160
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Schedule-Dependence in Cancer Therapy: What is the True Scenario for Vitamin C?

Duconge J, Miranda-Massari J, Gonzalez M, Riordan N Orthomolecular Medicine, 2007, 22(1):21-26
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Intravenously Administered Vitamin C as Cancer Therapy Three Cases

Padayatty S, Riordan H, Hewitt S, Katz A, Hoffer L, Levine M Canadian Medical Association Journal, 2006, 174(7):937-942
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Tumor Growth Parameters of In-Vivo Human Breast Carcinoma: A Proposed Mathematical Model for Tumor Growth Kinetics

Gonzalez M, Herrera F, Miranda-Massari J, Guzman A, Riordan N, Ricart C Puerto Rico Health Sciences Journal, 2006, 25(1):71-73
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A Pilot Clinical Study of Continuous Intravenous Ascorbate in Terminal Cancer Patients

Riordan H, Casciari J, Gonzalez M, Riordan N, Miranda-Massari J, Jackson J Puerto Rico Health Sciences Journal, 2005, 24(4):269-276
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Effects of High Dose Ascorbate Administration on L-10 Tumor Growth in Guinea Pigs

Casciari J, Riordan H, Miranda-Massari J, Gonzalez M Puerto Rico Health Sciences Journal, 2005, 24(2):145-150
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Orthomolecular Oncology Review: Ascorbic Acid and Cancer 25 Years Late

Gonzalez M, Miranda-Massari J, Mora E, Guzman A, Riordan N, Riordan H, Casciari J, Jackson J, Roman-Franco A Integrative Cancer Therapies, 2005, 4(1):32-44
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Activation of Raf1 and the ERK Pathway in Response to L-ascorbic Acid in Acute Myeloid Leukemia Cells

Park S, Park C, Hahm E, Kim K, Kimler B, Lee S, Park H, Lee S, Kim W, Jung C, Park K, Riordan H, Lee J Cellular Signalling, 2005, 17:111-119
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Intravenous Vitamin C as a Chemotherapy Agent: A Report on Clinical Cases

Riordan H, Riordan N, Jackson J, Casciari J, Hunninghake R, Gonzalez M, Mora E, Miranda-Massari J, Rosario N, Rivera A Puerto Rico Health Sciences Journal, 2004, 23(2):115-118
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Erythrocyte Membrane Fatty Acid Composition in Cancer Patients

Mikirova N, Riordan H, Jackson J, Wong K, Miranda-Massari J, Gonzalez M Puerto Rico Health Sciences Journal, 2004, 23(2):107-113
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Cell Membrane Fatty Acid Composition Differs Between Normal and Malignant Cell Lines

Meng X, Riordan N, Riordan H, Mikirova N, Jackson J, Gonzalez M, Miranda-Massari J, Mora E, Castillo W Puerto Rico Health Sciences Journal, 2004, 23(2):103-106
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L-Ascorbic Acid Induces Apoptosis in Acute Myeloid Leukemia Cells via Hydrogen Peroxide-Mediated Mechanisms

Park S, Han S, Park C, Hahm E, Lee S, Park H, Lee S, Kim W, Jung C, Park K, Riordan H, Kimler B, Kim K, Lee J International Journal of Biochemistry & Cell Biology, 2004, 36:2180-95
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L-Ascorbic Acid Represses Constitutive Activation of NF-KB and COX-2 Expression in Human Acute Myeloid Leukemia, HL-60

Han S, Kim K, Hahm E, Lee S, Surh Y, Park H, Kim W, Jung C, Lee M, Park K, Yang J, Yoon S, Riordan N, Riordan H, Kimler B, Park C, Lee J, Park S Journal of Cellular Biochemistry, 2004, 93(2):257-270
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Detection of Energy Metabolism Level in Cancer Patients by Fluorescence Emission from Serum

Mikirova NA, Riordan HD, Rillema P Orthomolecular Medicine, 2003, 18(1):9-24
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Urine Pyrroles in Patients with Cancer

Jackson J, Riordan H, Bramhall N, Neathery S Orthomolecular Medicine, 2003, 18(1):41-42
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Intravenous Ascorbic Acid: Protocol for its Application and Use

Riordan H, Hunninghake R, Riordan N, Jackson J, Meng X, Taylor P, Casciari J, Gonzalez M, Miranda-Massari J, Mora E, Rosario N, Rivera A Puerto Rico Health Sciences Journal, 2003, 22(3):287-290
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Effects of a High Molecular Mass Convolvulus Arvensis Extract on Tumor Growth and Angiogenesis

Meng X, Riordan N, Casciari J, Zhu Y, Zhong J, Gonzalez M, Miranda-Massari J, Riordan H Puerto Rico Health Sciences Journal, 2002, 21(4):323-328
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Orthomolecular Oncology: A Mechanistic View of Antravenous Ascorbate’s Chemotherapeutic Activity

Gonzalez M, Miranda-Massari J, Mora E, Jimenez I, Matos M, Riordan H, Casciari J, Riordan N, Rodriguez M, Guzman A Puerto Rico Health Sciences Journal, 2002, 21(1):39-41
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Inhibition of Human Breast Carcinoma Cell Proliferation by Ascorbate and Copper

Gonzalez M, Mora E, Miranda-Massari J, Matta E, Riordan H, Riordan N Puerto Rico Health Sciences Journal, 2002, 21(1):21-23
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Sixteen-Year History with High Dose Intravenous Vitamin C Treatment for Various Types of Cancer and Other Diseases

Jackson J, Riordan H, Bramhall N, Neathery S Orthomolecular Medicine, 2002, 17(2):117-119
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Cytotoxicity of Ascorbate, Lipoic Acid, and Other Antioxidants in Hollow Fibre in Vitro Tumours

Casciari J, Riordan N, Schmidt T, Meng X, Jackson J, Riordan H British Journal of Cancer, 2001, 84(11):1544-1550
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The Effect of Alternating Magnetic Field Exposure and Vitamin C on Cancer Cells

Mikirova N, Jackson J, Casciari, Riordan H Orthomolecular Medicine, 2001, 16(3):177-182
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Different Fatty Acid Composition Between Normal and Malignant Cell Lines

Meng X, Riordan N, Riordan H, Jackson J, Zhong J, Li Y, Gonzalez M, McClune B, Pappan K BioMedicina, 1999, 2(4):s5-s7 May
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Antioxidants as Chemopreventive Agents for Breast Cancer

Gonzalez M, Riordan N, Riordan H BioMedicina, 1998, 1(4):120-127 April
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High-Dose Intravenous Vitamin C in the Treatment of a Patient with Renal Cell Carcinoma of the Kidney

Riordan H, Jackson J, Riordan N, Schultz M Orthomolecular Medicine, 1998, 13(2):72-73
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Rethinking Vitamin C and Cancer: An Update on Nutritional Oncology

Gonzalez M, Mora E, Riordan N, Riordan H, Mojica P Cancer Prevention International, 1998, 3:215-224
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Intravenous Vitamin C in a Terminal Cancer Patient

Riordan N, Jackson J, Riordan H Orthomolecular Medicine, 1996, 11(2):80-82
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The Paradoxical Role of Lipid Peroxidation on Carcinogenesis and Tumor Growth: A Commentary

Gonzalez M, Riordan N Medical Hypotheses, 1996, 46(6):503-504
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High Dose Intravenous Vitamin C and Long Time Survival of a Patient with Cancer of Head of the Pancreas

Jackson J, Riordan H, Hunninghake R, Riordan N Orthomolecular Medicine, 1995, 10(2):87-88
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Intravenous Ascorbate as a Tumor Cytotoxic Chemotherapeutic Agent

Riordan N, Riordan H, Meng X, Li Y, Jackson J Medical Hypotheses, 1995, 44(3):207-213
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Improved Microplate Fluorometer Counting of Viable Tumor and Normal Cells

Riordan H, Riordan N, Meng X, Zhong J, Jackson J Anticancer Research, 1994, 14:927-931
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Case Study: High Dose Intravenous Vitamin C in the Treatment of a Patient with Adrenocarcinoma of the Kidney

Riordan H, Jackson J, Schultz Orthomolecular Medicine, 1990, 5(1):5-7
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