The action of strontium, a trace mineral, is closely related to that of calcium and the retention of strontium varies inversely with intake. It affects the osteoporotic process by inhibiting the activity of the 24, 25 hydroxy forms of vitamin D3 in animals. It has been shown that treating postmenopausal women with strontium ranelate leads to early and sustained reductions in the risk of vertebral fractures. Low levels have been found in patients with dental caries, decreased growth in animals, bone pain, and osteoporosis. Toxic levels may cause dental caries, rickets, abdominal pain, and diarrhea.
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