The Manganese (Mn) content in the adult human is 12 to 20 mg. About 25% is stored in the skeleton. Within each cell, Manganese is concentrated in the mitochondria. Bone, liver, and pancreas tend to have the highest concentrations.
Deficiency symptoms are unclear. There may be blood clotting defects, hypocholesterolemia, elevated serum calcium, phosphorus, and alkaline phosphatase. There may be loss of muscle tone, diabetes, and heart disease. Mn is an important part of the anti-oxidant enzyme super oxidase dismutase.
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