Hematogenous Oxidative Therapy (HOT) + Ultraviolet Blood Irradiation (UBI) with Intravenous Vitamin C

Available in Wichita and Overland Park

When symptoms persist, it can be hard to know what is worth trying next.

If you have been experiencing fatigue, brain fog, breathing changes, or other symptoms that are not resolving, it is common to feel frustrated and unsure where to turn.

HOT UBI with IVC may be an option once we obtain your full history, current care, and long-term goals. The next step is a provider appointment. If it is a fit for your health journey, your provider may recommend it as part of your care plan.

Who This Approach May Be Considered For

HOT UBI with IVC may be considered as part of a provider-directed plan for co-learners who are:

• Experiencing ongoing fatigue, brain fog, or changes in recovery after illness
• Navigating post-viral symptoms, including Long COVID
• Looking for additional support alongside current care

• Learn More About Long COVID emerging research
  

  Many people recover fully after COVID. Some do not, and may experience ongoing fatigue, brain fog, shortness of breath, muscle discomfort, or digestive changes for months (or longer). This pattern is often called “Long COVID.”Research into Long COVID is evolving. One area being explored involves the body’s smallest blood vessels (the microcirculation) and how changes there may affect oxygen delivery to different tissues.

  Related: New Hope for Long COVID (Article) | Real Health Podcast (link coming soon)

  Microclots and Microcirculation (What We’re Watching)

  Emerging research has described tiny fibrin-rich structures sometimes referred to as “microclots,” along with related immune activity such as neutrophil extracellular traps (NETs).

  Unlike large clots associated with heart attacks or strokes, microclots are microscopic and are not typically seen on standard imaging. Researchers are investigating whether these changes may contribute to uneven (“spotty”) oxygen delivery in the body’s smallest vessels.

  D-dimer: A Lab Marker

  D-dimer is a blood test that measures fragments produced when fibrin clots break down. In some clinical contexts, it can help indicate increased clotting activity.

  At Riordan Clinic, providers consider D-dimer as one piece of a broader evaluation. D-dimer does not diagnose Long COVID, and a normal D-dimer does not necessarily rule out Long COVID. Decisions are made in the context of your full clinical picture.

What Is Riordan HOT UBI with IVC?

HOT UBI with IVC is a provider-directed therapy that involves treating a small amount of blood outside the body and reinfusing it as part of a broader care plan.

• Hematogenous Oxidative Therapy (HOT)
• Ultraviolet Blood Irradiation (UBI)
• Intravenous Vitamin C (IVC) to reduce oxidative stress

HOT and UBI have been used historically in medicine as early as the 1950s. This approach builds on the therapeutic principles of ultraviolet blood irradiation (UBI), combined with 100% oxygen and Riordan Clinic’s pioneering research on the safe use of high-dose intravenous C. Learn more: https://riordanclinic.org/what-we-do/ultraviolet-blood-irradiation/ 

At Riordan Clinic, a small amount of blood is withdrawn, exposed to controlled ultraviolet light and oxygen, and then reinfused, followed by IVC.

Your provider reviews your medical history, medications, and relevant laboratory findings before recommending this approach.

What To Expect During a Visit

If your provider determines this approach is appropriate, your care team will review timing, preparation, and monitoring in advance.

A typical treatment visit includes:

1. Placement of an IV and withdrawal of a small amount of blood (often about 45 mL)
2. Controlled ultraviolet exposure while the blood is mixed with medical-grade oxygen (about a 3-minute treatment cycle)
3. Reinfusion of the treated blood (often over ~20 minutes)
4. Intravenous vitamin C (dose and infusion time are individualized)

Visit length can vary depending on your individualized plan.

How Many Sessions Might Be Recommended?

Your provider will tailor recommendations based on symptoms, history, and goals. Some co-learners may be advised to complete two sessions spaced about 48 hours apart, while others may need a different plan.

After Treatment

Some co-learners report temporary effects such as:

• Bruising at the injection site
• Flu-like symptoms within 24 hours
• Facial flushing
• A temporary rise in temperature

Your provider will review what to watch for and when to contact the clinic.

Seek immediate medical care for severe reactions or concerning symptoms.

How This Fits Into Your Care

The published literature has described ultraviolet blood irradiation and explored its potential effects on immune signaling and microcirculation. Research is evolving.

At Riordan Clinic, we follow emerging research and use careful clinical judgment. When HOT UBI with IVC is considered, it is used within a broader plan. Providers may monitor symptoms and, when appropriate, laboratory markers over time.

Safety Considerations

Before recommending this approach, your provider reviews:

• Medical history
• Current medications
• Relevant laboratory findings
• Safety factors specific to you

In some medical situations, this approach may not be appropriate, including:

• G6PD deficiency
• Severe cardiovascular instability
• Active bleeding disorders
• Pregnancy
• Recent chemotherapy

Final determination is made by your provider.

Regulatory Information

Ultraviolet blood irradiation has been described in published literature. For clarity:

• It is considered investigational
• It is not approved by the FDA for the treatment of specific diseases
• It is not considered standard of care
• Services may not be billable to insurance
• Risks, benefits, and alternatives are reviewed during your provider appointment

References

1. Pretorius E, et al. Circulating microclots are structurally associated with neutrophil extracellular traps and are elevated in Long COVID patients. Journal of Medical Virology. October 2025.
2. Levy TE. Curing Long COVID and Associated Hypercoagulation. Shanghai Salon Zoom Dialogue, February 24, 2026.
3. Knott EK. Historical observations on ultraviolet blood irradiation therapy.