Selenium (Se) is a constituent of glutathione peroxidase, an antioxidant enzyme that breaks down hydrogen peroxide, phospholipid hydroperoxide, and other free hydroperoxides. There are four selenium atoms in glutathione peroxidase. There are three types of iodothyronine deiodinase. It removes iodine from thyroid hormone molecules, activates T4, and inactivates T3. Type I in the cells of the liver, kidney, and thyroid converts T3 from T4. Type II is found in the brain, brown fat, and pituitary, and converts T4 to T3 and regulates TSH secretion. Type III inactivates T3.
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