Pyrroles, Urine (3 collections) (Pyrroluria, Kryptopyrrole, Mauve Factor)

A urine test for diagnosis and monitoring severe physiological or psychological stress.

Pyrroles appear in the urine of patients undergoing severe physiological or psychological stress. The presence of urinary pyrroles (mauve factor) was first reported in patients with LSD psychosis. Later, high levels of pyrroles were found in the urine of schizophrenic patients. The chemical structure is a 2,4 dimethyl-3-ethylpyrrole. It is also called kryptopyrrole. Kryptos comes from the Greek word “hidden.”

In normal urine, the amount of pyrroles excreted is small, less than 20 ug/dL. It has been reported that kryptopyrrole will form a Shiff base with the aldehyde form of vitamin B6 in the blood. This combination will then bind with zinc. As large amounts of kryptopyrroles are excreted in the urine, it depletes the blood of B6 and zinc.

Urine specimen collection and transport are very important for proper test results. Kits for shipping can be obtained from the laboratory. A brown plastic tube containing 500 mg of ascorbic acid (vitamin C) is filled with urine, no less than 1/2 full and no more than 3/4 full. The urine is mixed and frozen. Ship frozen with a cold pack by overnight delivery.

A more comprehensive evaluation of pyrrole excretion may be done by collecting 3 specimens:

  • Specimen #1: Collected in a calm mental state
  • Specimen #2: Collected in an anxious mental state
  • Specimen #3: Collected in an extremely anxious mental state.

Note: Label specimens carefully with each condition.

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