Riordan Clinic Scientist Publishes Study

Riordan Clinic Scientist Publishes Study “Increased Level of Circulating Endothelial Microparticles and Cardiovascular Risk Factors”

Wichita, KS USA Monday, May 16, 2011

Riordan Clinic Senior Research Scientist Dr. Nina Mikirova had an article published in the Journal of Clinical and Experimental Cardiology entitled Increased Level of Circulating Endothelial Microparticles and Cardiovascular Risk Factors.

The research study found that cellular endothelial microparticles (EMP), determined in plasma by specific antibodies, provide an early indicator of cardiovascular risk. Increased levels of EMP can initiate atherosclerosis by promoting endothelial dysfunction and arterial wall inflammation and they also may contribute to plaque progression and rupture.

Cellular microparticles are small plasma membrane vesicles composed primarily of lipids and proteins. They are shed from mature endothelial cells on stimulation by activating agents and under the stress conditions. Microparticles circulate at low levels in healthy individuals. Elevated circulation of EMPs indicates exposure of endothelial cells to unfavorable conditions.

Although EMPs are an emerging marker in the assessment of cardiovascular risk, as demonstrated by the published study, their elevated circulation is already recognized in a number of pathologic states. Patients with illnesses such as lupus anticoagulant, cardiovascular disease, arterial hypertension, hypertriglyceridemia, thrombosis, renal failure, diabetes and multiple sclerosis show elevated EMP levels.

The Riordan Clinic is a progressive nutrition-based medical clinic located in Wichita, Kansas. For 35 years, the Riordan Clinic has integrated lifestyle and nutrition to help patients find the underlying causes of their illness. Since the inception in 1975, the mission has been clear and unwavering to “…stimulate an epidemic of health.”
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